For such honeycomb structures, you can analyze periodic segments / RVEs or unit cells. You will find many examples for various hexagonal honeycombs (also reinforced in different ways) in literature.
(A method of determining effective elastic properties of honeycomb cores based on equal strain energy - ScienceDirect)
Normally, this requires periodic BCs (sometimes regular symmetry is used though) and you can find more information about that here: How to apply symmetry to honeycomb core unit cells